Chicken HS4 Insulators Have Minimal Barrier Function Among Progeny of Human Hematopoietic Cells Transduced With an HIV1-based Lentiviral Vector

Position effects limit the curative potential of gene transfer strategies for the hemoglobinopathies by inducing clonal variability of transgene expression. We evaluated the mitigating effects of the chicken hypersensitivity site 4 (HS4) insulator among lentiviral vector-transduced human hematopoiet...

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Detalhes bibliográficos
Main Authors: Uchida, Naoya, Washington, Kareem N, Lap, Coen J, Hsieh, Matthew M, Tisdale, John F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017448/
https://ncbi.nlm.nih.gov/pubmed/20940706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.218
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