Optimized Lentiviral Vector Design Improves Titer and Transgene Expression of Vectors Containing the Chicken β-Globin Locus HS4 Insulator Element

Hematopoietic cell gene therapy using retroviral vectors has achieved success in clinical trials. However, safety issues regarding vector insertional mutagenesis have emerged. In two different trials, vector insertion resulted in the transcriptional activation of proto-oncogenes. One strategy for po...

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Detaylı Bibliyografya
Asıl Yazarlar: Hanawa, Hideki, Yamamoto, Motoko, Zhao, Huifen, Shimada, Takashi, Persons, Derek A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2009
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835111/
https://ncbi.nlm.nih.gov/pubmed/19223867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.1
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