Optimized Lentiviral Vector Design Improves Titer and Transgene Expression of Vectors Containing the Chicken β-Globin Locus HS4 Insulator Element

Hematopoietic cell gene therapy using retroviral vectors has achieved success in clinical trials. However, safety issues regarding vector insertional mutagenesis have emerged. In two different trials, vector insertion resulted in the transcriptional activation of proto-oncogenes. One strategy for po...

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Autori principali: Hanawa, Hideki, Yamamoto, Motoko, Zhao, Huifen, Shimada, Takashi, Persons, Derek A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2009
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835111/
https://ncbi.nlm.nih.gov/pubmed/19223867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.1
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