Optimized Lentiviral Vector Design Improves Titer and Transgene Expression of Vectors Containing the Chicken β-Globin Locus HS4 Insulator Element

Hematopoietic cell gene therapy using retroviral vectors has achieved success in clinical trials. However, safety issues regarding vector insertional mutagenesis have emerged. In two different trials, vector insertion resulted in the transcriptional activation of proto-oncogenes. One strategy for po...

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Detalhes bibliográficos
Main Authors: Hanawa, Hideki, Yamamoto, Motoko, Zhao, Huifen, Shimada, Takashi, Persons, Derek A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835111/
https://ncbi.nlm.nih.gov/pubmed/19223867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.1
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