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Mobilization and Mechanism of Transcription of Integrated Self-Inactivating Lentiviral Vectors

Permanent genetic modification of replicating primitive hematopoietic cells by an integrated vector has many potential therapeutic applications. Both oncoretroviral and lentiviral vectors have a predilection for integration into transcriptionally active genes, creating the potential for promoter act...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Hanawa, Hideki, Persons, Derek A., Nienhuis, Arthur W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143763/
https://ncbi.nlm.nih.gov/pubmed/15956585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.13.8410-8421.2005
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