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p27: A Barometer of Signaling Deregulation and Potential Predictor of Response to Targeted Therapies

Phosphorylation of the cyclin-dependent kinase inhibitor p27 by upstream mitogenic signaling pathways regulates its stability, localization and biological function. In human cancers, loss of the antiproliferative action of p27 can arise through reduced protein levels and/or cytoplasmic mislocalizati...

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Detalhes bibliográficos
Main Authors: Wander, Seth A., Zhao, Dekuang, Slingerland, Joyce M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017239/
https://ncbi.nlm.nih.gov/pubmed/20966355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0752
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