p27 transcriptionally coregulates cJun to drive programs of tumor progression

p27 shifts from CDK inhibitor to oncogene when phosphorylated by PI3K effector kinases. Here, we show that p27 is a cJun coregulator, whose assembly and chromatin association is governed by p27 phosphorylation. In breast and bladder cancer cells with high p27pT157pT198 or expressing a CDK-binding de...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Yoon, Hyunho, Kim, Minsoon, Jang, Kibeom, Shin, Miyoung, Besser, Alexandra, Xiao, Xue, Zhao, Dekuang, Wander, Seth A., Briegel, Karoline, Morey, Lluis, Minn, Andy, Slingerland, Joyce M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
PNAS Plus
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452716/
https://ncbi.nlm.nih.gov/pubmed/30877256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817415116
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