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Molecularly targeted therapies for p53-mutant cancers
The tumor suppressor p53 is lost or mutated in approximately half of human cancers. Mutant p53 not only loses its anti-tumor transcriptional activity, but also often acquires oncogenic functions to promote tumor proliferation, invasion, and drug resistance. Traditional strategies have been taken to...
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| Publicado no: | Cell Mol Life Sci |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5664959/ https://ncbi.nlm.nih.gov/pubmed/28643165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-017-2575-0 |
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