Defining the Role of APC in the Mitotic Spindle Checkpoint In Vivo: APC Deficient Cells Are Resistant to Taxol

Mutations in the adenomatous polyposis coli (APC) tumour suppressor are the key initiating event of colorectal cancer. Although the control of WNT signaling is well established as a central tumour suppressive function, the significance of APC in regulating chromosome instability is less well establi...

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Autori principali: Radulescu, Sorina, Ridgway, Rachel A, Appleton, Paul, Kroboth, Karin, Patel, Satish, Woodgett, James, Taylor, Stephen, Nathke, Inke S, Sansom, Owen J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016607/
https://ncbi.nlm.nih.gov/pubmed/20729907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.373
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