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Stiffness Gradients Mimicking In Vivo Tissue Variation Regulate Mesenchymal Stem Cell Fate
Mesenchymal stem cell (MSC) differentiation is regulated in part by tissue stiffness, yet MSCs can often encounter stiffness gradients within tissues caused by pathological, e.g., myocardial infarction ∼8.7±1.5 kPa/mm, or normal tissue variation, e.g., myocardium ∼0.6±0.9 kPa/mm; since migration pre...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3016411/ https://ncbi.nlm.nih.gov/pubmed/21246050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015978 |
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