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Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels

The spatial presentation of mechanical information is a key parameter for cell behavior. We have developed a method of polymerization control in which the differential diffusion distance of unreacted cross-linker and monomer into a prepolymerized hydrogel sink results in a tunable stiffness gradient...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hadden, William J., Young, Jennifer L., Holle, Andrew W., McFetridge, Meg L., Kim, Du Yong, Wijesinghe, Philip, Taylor-Weiner, Hermes, Wen, Jessica H., Lee, Andrew R., Bieback, Karen, Vo, Ba-Ngu, Sampson, David D., Kennedy, Brendan F., Spatz, Joachim P., Engler, Adam J., Choi, Yu Suk
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465928/
https://ncbi.nlm.nih.gov/pubmed/28507138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618239114
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