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Stiffness Gradients Mimicking In Vivo Tissue Variation Regulate Mesenchymal Stem Cell Fate

Mesenchymal stem cell (MSC) differentiation is regulated in part by tissue stiffness, yet MSCs can often encounter stiffness gradients within tissues caused by pathological, e.g., myocardial infarction ∼8.7±1.5 kPa/mm, or normal tissue variation, e.g., myocardium ∼0.6±0.9 kPa/mm; since migration pre...

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Detalhes bibliográficos
Main Authors: Tse, Justin R., Engler, Adam J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016411/
https://ncbi.nlm.nih.gov/pubmed/21246050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015978
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