qPCR in gastrointestinal stromal tumors: Evaluation of reference genes and expression analysis of KIT and the alternative receptor tyrosine kinases FLT3, CSF1-R, PDGFRB, MET and AXL

BACKGROUND: Gastrointestinal stromal tumors (GIST) represent the most common mesenchymal tumors of the gastrointestinal tract. About 85% carry an activating mutation in the KIT or PDGFRA gene. Approximately 10% of GIST are so-called wild type GIST (wt-GIST) without mutations in the hot spots. In the...

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Hauptverfasser: Fassunke, Jana, Blum, Marie-Christine, Schildhaus, Hans-Ulrich, Zapatka, Marc, Brors, Benedikt, Künstlinger, Helen, Büttner, Reinhard, Wardelmann, Eva, Merkelbach-Bruse, Sabine
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014927/
https://ncbi.nlm.nih.gov/pubmed/21171987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-11-100
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