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Chk-ing in and Chk-ing out: Kinase compartmentalization comes to checkpoint control
Checkpoints are the sentinels of cell-cycle progression. In this issue, Yaffe and colleagues (Reinhardt et al., 2010) show that spatial and temporal resolution of Chk1 and MK2, checkpoint kinases with identical substrate specificity, are necessary to signal different aspects of DNA damage signaling.
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3014293/ https://ncbi.nlm.nih.gov/pubmed/20932468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.09.020 |
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