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Antiviral Effects of a Transgenic RNA-Dependent RNA Polymerase

Transgenic expression of the RNA-dependent RNA polymerase 3D(pol) inhibited infection of Theiler's murine encephalitis virus (TMEV), a picornavirus from which it was derived. Here, we infected 3D(pol) transgenic mice with another picornavirus, as well as an alphaherpesvirus and a rhabdovirus. 3...

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Autors principals: Kerkvliet, Jason, Papke, Louisa, Rodriguez, Moses
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014166/
https://ncbi.nlm.nih.gov/pubmed/20962089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01626-10
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