Unraveling the Binding Mechanism of Trivalent Tumor Necrosis Factor Ligands and Their Receptors

Characterization of the binding of a tumor necrosis factor (TNF) ligand to its receptor(s) is pivotal to understand how these proteins initiate signal transduction pathways. Unfortunately, kinetic elucidation of these interactions is strongly hampered by the multivalent nature of the binding partner...

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Bibliografiske detaljer
Main Authors: Reis, Carlos R., van Assen, Aart H. G., Quax, Wim J., Cool, Robbert H.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013454/
https://ncbi.nlm.nih.gov/pubmed/20852190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M110.002808
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