Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potential anticancer drug that selectively induces apoptosis in a variety of cancer cells by interacting with death receptors DR4 and DR5. TRAIL can also bind to decoy receptors (DcR1, DcR2, and osteoprotegerin receptor) that canno...

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Bibliografiske detaljer
Main Authors: van der Sloot, Almer M., Tur, Vicente, Szegezdi, Eva, Mullally, Margaret M., Cool, Robbert H., Samali, Afshin, Serrano, Luis, Quax, Wim J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482632/
https://ncbi.nlm.nih.gov/pubmed/16731632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510187103
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