Role of MSK1 in the Malignant Phenotype of Ras-transformed Mouse Fibroblasts

Activated by the RAS-MAPK signaling pathway, MSK1 is recruited to immediate-early gene (IEG) regulatory regions, where it phosphorylates histone H3 at Ser-10 or Ser-28. Chromatin remodelers and modifiers are then recruited by 14-3-3 proteins, readers of phosphoserine marks, leading to the occupancy...

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Bibliografiske detaljer
Main Authors: Pérez-Cadahía, Beatriz, Drobic, Bojan, Espino, Paula S., He, Shihua, Mandal, Soma, Healy, Shannon, Davie, James R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013000/
https://ncbi.nlm.nih.gov/pubmed/21071437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.156687
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