Role of MSK1 in the Malignant Phenotype of Ras-transformed Mouse Fibroblasts

Activated by the RAS-MAPK signaling pathway, MSK1 is recruited to immediate-early gene (IEG) regulatory regions, where it phosphorylates histone H3 at Ser-10 or Ser-28. Chromatin remodelers and modifiers are then recruited by 14-3-3 proteins, readers of phosphoserine marks, leading to the occupancy...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pérez-Cadahía, Beatriz, Drobic, Bojan, Espino, Paula S., He, Shihua, Mandal, Soma, Healy, Shannon, Davie, James R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2011
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013000/
https://ncbi.nlm.nih.gov/pubmed/21071437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.156687
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