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Role of MSK1 in the Malignant Phenotype of Ras-transformed Mouse Fibroblasts
Activated by the RAS-MAPK signaling pathway, MSK1 is recruited to immediate-early gene (IEG) regulatory regions, where it phosphorylates histone H3 at Ser-10 or Ser-28. Chromatin remodelers and modifiers are then recruited by 14-3-3 proteins, readers of phosphoserine marks, leading to the occupancy...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3013000/ https://ncbi.nlm.nih.gov/pubmed/21071437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.156687 |
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