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Metformin Activates AMP Kinase through Inhibition of AMP Deaminase
The mechanism for how metformin activates AMPK (AMP-activated kinase) was investigated in isolated skeletal muscle L6 cells. A widely held notion is that inhibition of the mitochondrial respiratory chain is central to the mechanism. We also considered other proposals for metformin action. As metabol...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3012963/ https://ncbi.nlm.nih.gov/pubmed/21059655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.121806 |
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