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Up-regulation of AMP-activated Protein Kinase in Cancer Cell Lines Is Mediated through c-Src Activation

We report that the activation level of AMP-dependent protein kinase AMPK is elevated in cancer cell lines as a hallmark of their transformed state. In OVCAR3 and A431 cells, c-Src signals through protein kinase Cα, phospholipase Cγ, and LKB1 to AMPK. AMPK controls internal ribosome entry site (IRES)...

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Detalhes bibliográficos
Main Authors: Mizrachy-Schwartz, Sarit, Cohen, Noam, Klein, Shoshana, Kravchenko-Balasha, Nataly, Levitzki, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083231/
https://ncbi.nlm.nih.gov/pubmed/21245141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.211813
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