miR-200a Prevents Renal Fibrogenesis Through Repression of TGF-β2 Expression

OBJECTIVE: Progressive fibrosis in the diabetic kidney is driven and sustained by a diverse range of profibrotic factors. This study examines the critical role of microRNAs (miRNAs) in the regulation of the key fibrotic mediators, TGF-β1 and TGF-β2. RESEARCH DESIGN AND METHODS: Rat proximal-tubular...

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Main Authors: Wang, Bo, Koh, Philip, Winbanks, Catherine, Coughlan, Melinda T., McClelland, Aaron, Watson, Anna, Jandeleit-Dahm, Karin, Burns, Wendy C., Thomas, Merlin C., Cooper, Mark E., Kantharidis, Phillip
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2011
Teme:
Complications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012183/
https://ncbi.nlm.nih.gov/pubmed/20952520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0892
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