Alagebrium Reduces Glomerular Fibrogenesis and Inflammation Beyond Preventing RAGE Activation in Diabetic Apolipoprotein E Knockout Mice

Advanced glycation end products (AGEs) are important mediators of diabetic nephropathy that act through the receptor for AGEs (RAGE), as well as other mechanisms, to promote renal inflammation and glomerulosclerosis. The relative contribution of RAGE-dependent and RAGE-independent signaling pathways...

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Главные авторы: Watson, Anna M.D., Gray, Stephen P., Jiaze, Li, Soro-Paavonen, Aino, Wong, Benedict, Cooper, Mark E., Bierhaus, Angelika, Pickering, Raelene, Tikellis, Christos, Tsorotes, Despina, Thomas, Merlin C., Jandeleit-Dahm, Karin A.M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2012
Предметы:
Complications
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402321/
https://ncbi.nlm.nih.gov/pubmed/22698914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1546
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