Antiatherosclerotic and Renoprotective Effects of Ebselen in the Diabetic Apolipoprotein E/GPx1-Double Knockout Mouse

OBJECTIVE: To investigate the effect of the GPx1-mimetic ebselen on diabetes-associated atherosclerosis and renal injury in a model of increased oxidative stress. RESEARCH DESIGN AND METHODS: The study was performed using diabetic apolipoprotein E/GPx1 (ApoE(−/−)GPx1(−/−))-double knockout (dKO) mice...

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Hauptverfasser: Chew, Phyllis, Yuen, Derek Y.C., Stefanovic, Nada, Pete, Josefa, Coughlan, Melinda T., Jandeleit-Dahm, Karin A., Thomas, Merlin C., Rosenfeldt, Franklin, Cooper, Mark E., de Haan, Judy B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2010
Schlagworte:
Complications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992783/
https://ncbi.nlm.nih.gov/pubmed/20823099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0195
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