Cell Type Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward

The nucleus accumbens is a key mediator of cocaine reward, but the distinct roles of the two subpopulations of nucleus accumbens projection neurons, those expressing dopamine D1 vs. D2 receptors, are poorly understood. We show that deletion of TrkB, the brain-derived neurotrophic factor (BDNF) recep...

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主要な著者: Lobo, Mary Kay, Covington, Herbert E., Chaudhury, Dipesh, Friedman, Allyson K., Sun, HaoSheng, Damez-Werno, Diane, Dietz, David, Zaman, Samir, Koo, Ja Wook, Kennedy, Pamela J., Mouzon, Ezekiell, Mogri, Murtaza, Neve, Rachael L., Deisseroth, Karl, Han, Ming-Hu, Nestler, Eric J.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3011229/
https://ncbi.nlm.nih.gov/pubmed/20947769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1188472
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