Cell Type Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward

The nucleus accumbens is a key mediator of cocaine reward, but the distinct roles of the two subpopulations of nucleus accumbens projection neurons, those expressing dopamine D1 vs. D2 receptors, are poorly understood. We show that deletion of TrkB, the brain-derived neurotrophic factor (BDNF) recep...

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Autori principali: Lobo, Mary Kay, Covington, Herbert E., Chaudhury, Dipesh, Friedman, Allyson K., Sun, HaoSheng, Damez-Werno, Diane, Dietz, David, Zaman, Samir, Koo, Ja Wook, Kennedy, Pamela J., Mouzon, Ezekiell, Mogri, Murtaza, Neve, Rachael L., Deisseroth, Karl, Han, Ming-Hu, Nestler, Eric J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3011229/
https://ncbi.nlm.nih.gov/pubmed/20947769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1188472
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