A Novel DNA Topoisomerase I Inhibitor with Different Mechanism from Camptothecin Induces G2/M Phase Cell Cycle Arrest to K562 Cells

DNA topoisomerase I (Top1) is an essential nuclear enzyme and a validated target for anticancer agent screening. In a previous study, we found that indolizinoquinoline-5,12-dione derivatives show significant biological activity against several human cancer cell lines. To understand their mechanism o...

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Detalhes bibliográficos
Main Authors: Wu, Ning, Wu, Xi-Wei, Agama, Keli, Pommier, Yves, Du, Jun, Li, Ding, Gu, Lian-Quan, Huang, Zhi-Shu, An, Lin-Kun
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010555/
https://ncbi.nlm.nih.gov/pubmed/21033700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1009419
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