Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain

BACKGROUND: Neuropathic pain is characterized by hypersensitivity to innocuous stimuli (tactile allodynia) that is nearly always resistant to NSAIDs or even opioids. Gabapentin, a GABA analogue, was originally developed to treat epilepsy. Accumulating clinical evidence supports the effectiveness of...

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Main Authors: Kusunose, Naoki, Koyanagi, Satoru, Hamamura, Kengo, Matsunaga, Naoya, Yoshida, Miyako, Uchida, Takahiro, Tsuda, Makoto, Inoue, Kazuhide, Ohdo, Shigehiro
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009974/
https://ncbi.nlm.nih.gov/pubmed/21108841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-6-83
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