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Proliferating Cell Nuclear Antigen-dependent Rapid Recruitment of Cdt1 and CRL4(Cdt2) at DNA-damaged Sites after UV Irradiation in HeLa Cells
The licensing factor Cdt1 is degraded by CRL4(Cdt2) ubiquitin ligase dependent on proliferating cell nuclear antigen (PCNA) during S phase and when DNA damage is induced in G(1) phase. Association of both Cdt2 and PCNA with chromatin was observed in S phase and after UV irradiation. Here we used a m...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3009925/ https://ncbi.nlm.nih.gov/pubmed/20929861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.161661 |
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