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Insights into Radicicol Biosynthesis via Heterologous Synthesis of Intermediates and Analogs
Resorcylic acid lactones are fungal polyketides that display diverse biological activities, with the potent Hsp90 inhibitor radicicol being an important representative member. Two fungal iterative polyketide synthases (IPKSs), Rdc5, the highly reducing IPKS, and Rdc1, the nonreducing IPKS, are requi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3009867/ https://ncbi.nlm.nih.gov/pubmed/20961859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.183574 |
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