γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23 dependent mechanism

Mice that lack interleukin-23 (IL-23) are resistant to T cell-mediated autoimmunity. Although IL-23 is a maturation factor for T helper 17 (Th17) cells, a subset of γδ T cells expresses the IL-23 receptor (IL-23R) constitutively. Using IL-23R reporter mice, we showed that γδ T cells were the first c...

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Detalhes bibliográficos
Main Authors: Petermann, Franziska, Rothhammer, Veit, Claussen, Malte C., Haas, Jan D., Riol Blanco, Lorena, Heink, Sylvia, Prinz, Immo, Hemmer, Bernhard, Kuchroo, Vijay K., Oukka, Mohamed, Korn, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008772/
https://ncbi.nlm.nih.gov/pubmed/20832339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.08.013
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