Proximity of the Start Codon to a Leaderless mRNA's 5′ Terminus Is a Strong Positive Determinant of Ribosome Binding and Expression in Escherichia coli

An AUG start codon is an important determinant of ribosome binding and expression of leaderless mRNAs in Escherichia coli. Using reporter constructs encoding mRNAs where the AUG start codon is preceded by untranslated leaders of various length and sequence, we find that close proximity of the start...

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Bibliographic Details
Main Authors: Krishnan, Karthik M., Van Etten, William J., Janssen, Gary R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008523/
https://ncbi.nlm.nih.gov/pubmed/20971908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00756-10
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