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Preferential Selection of the 5′-Terminal Start Codon on Leaderless mRNAs by Mammalian Mitochondrial Ribosomes

Mammalian mitochondrial mRNAs are basically leaderless, having few or no untranslated nucleotides prior to the 5′-start codon. We demonstrate here that mammalian mitochondrial 55 S ribosomes preferentially form initiation complexes at a 5′-terminal AUG codon over an internal AUG. The preferential us...

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Detalhes bibliográficos
Main Authors: Christian, Brooke E., Spremulli, Linda L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934702/
https://ncbi.nlm.nih.gov/pubmed/20610392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.149054
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