Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus

The restriction of viral receptors and coreceptors to the basolateral surface of airway epithelial cells has been blamed for the inefficient transfer of viral vectors to the apical surface of this tissue. We now report, however, that differentiated human airway epithelia internalize rAAV type-2 viru...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Duan, Dongsheng, Yue, Yongping, Yan, Ziying, Yang, Jusan, Engelhardt, John F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2000
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC300848/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10841516/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8317
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