EGFR and mutant p53 expand esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors

Transforming growth factor (TGF)-β is a potent inducer of epithelial to mesenchymal transition (EMT). However, it remains elusive as to which molecular mechanisms determine the cellular capacity to undergo EMT in response to TGF-β. We have found that both epidermal growth factor receptor (EGFR) over...

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Hauptverfasser: Ohashi, Shinya, Natsuizaka, Mitsuteru, Wong, Gabrielle S., Michaylira, Carmen Z., Grugan, Katharine D., Stairs, Douglas B., Kalabis, Jiri, Vega, Maria E., Kalman, Ross A., Nakagawa, Momo, Klein-Szanto, Andres J, Herlyn, Meenhard, Diehl, J. Alan, Rustgi, Anil K., Nakagawa, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007622/
https://ncbi.nlm.nih.gov/pubmed/20424117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4614
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