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Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation

Wilms tumor (WT) is a genetically heterogeneous childhood kidney tumor. Several genetic alterations have been identified in WT patients, including inactivating mutations in WT1 and loss of heterozygosity or loss of imprinting at 11p15, which results in biallelic expression of IGF2. However, the mech...

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Detaylı Bibliyografya
Asıl Yazarlar: Hu, Qianghua, Gao, Fei, Tian, Weihua, Ruteshouser, E. Cristy, Wang, Yaqing, Lazar, Alexander, Stewart, John, Strong, Louise C., Behringer, Richard R., Huff, Vicki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007149/
https://ncbi.nlm.nih.gov/pubmed/21123950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43772
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