Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation

Wilms tumor (WT) is a genetically heterogeneous childhood kidney tumor. Several genetic alterations have been identified in WT patients, including inactivating mutations in WT1 and loss of heterozygosity or loss of imprinting at 11p15, which results in biallelic expression of IGF2. However, the mech...

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Detalhes bibliográficos
Main Authors: Hu, Qianghua, Gao, Fei, Tian, Weihua, Ruteshouser, E. Cristy, Wang, Yaqing, Lazar, Alexander, Stewart, John, Strong, Louise C., Behringer, Richard R., Huff, Vicki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Technical Advance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007149/
https://ncbi.nlm.nih.gov/pubmed/21123950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43772
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