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Identification of germline DICER1 mutations and loss of heterozygosity in familial Wilms tumor using whole genome sequencing

Wilms tumor (WT), a pediatric renal cancer, is the most common childhood kidney cancer. The etiology of WT is heterogeneous with multiple genes known to result in WT tumorigenesis. However, these genes are rarely associated with familial Wilms tumor (FWT). To identify mutations predisposing to FWT,...

詳細記述

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書誌詳細
出版年:J Med Genet
主要な著者: Huff, Vicki, Palculict, Timothy Blake, Ruteshouser, E. Cristy, Fan, Yu, Wang, Wenyi, Strong, Louise
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866907/
https://ncbi.nlm.nih.gov/pubmed/26566882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmedgenet-2015-103311
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