Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

The Hedgehog (Hh) pathway is activated in some human cancers, including medulloblastoma. The glioma-associated oncogene homolog (GLI) transcription factors are critical mediators of the activated Hh pathway, and their expression may be elevated in some tumors independent of upstream Hh signaling. Th...

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Bibliografske podrobnosti
Main Authors: Beauchamp, Elspeth M., Ringer, Lymor, Bulut, Gülay, Sajwan, Kamal P., Hall, Michael D., Lee, Yi-Chien, Peaceman, Daniel, Özdemirli, Metin, Rodriguez, Olga, Macdonald, Tobey J., Albanese, Chris, Toretsky, Jeffrey A., Üren, Aykut
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007144/
https://ncbi.nlm.nih.gov/pubmed/21183792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42874
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