Arsenic Trioxide Prevents Osteosarcoma Growth by Inhibition of GLI Transcription via DNA Damage Accumulation

The Hedgehog pathway is activated in various types of malignancies. We previously reported that inhibition of SMO or GLI prevents osteosarcoma growth in vitro and in vivo. Recently, it has been reported that arsenic trioxide (ATO) inhibits cancer growth by blocking GLI transcription. In this study,...

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Main Authors: Nakamura, Shunsuke, Nagano, Satoshi, Nagao, Hiroko, Ishidou, Yasuhiro, Yokouchi, Masahiro, Abematsu, Masahiko, Yamamoto, Takuya, Komiya, Setsuro, Setoguchi, Takao
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704531/
https://ncbi.nlm.nih.gov/pubmed/23861973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069466
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