Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002

The Hedgehog (Hh) signaling pathway not only plays important roles in embryogenesis and adult tissue homeostasis, but also in tumorigenesis. Aberrant Hh pathway activation has been reported in a variety of malignant tumors including colon carcinoma. Here, we sought to investigate the regulation of t...

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Bibliografiske detaljer
Udgivet i:Onco Targets Ther
Main Authors: Cai, Xinyi, Yu, Kun, Zhang, Lijuan, Li, Yunfeng, Li, Qiang, Yang, Zhibin, Shen, Tao, Duan, Lincan, Xiong, Wei, Wang, Weiya
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2015
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407746/
https://ncbi.nlm.nih.gov/pubmed/25945059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S71034
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