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Limiting an Antimicrobial Peptide to the Lipid-Water Interface Enhances its Bacterial Membrane Selectivity – A Case Study on MSI-367
In a minimalist design approach, a synthetic peptide MSI-367 [(KFAKKFA)(3)-NH(2))] was designed and synthesized with an objective towards generating cell-selective non-lytic peptides, which have a significant bearing in cell-targeting. The peptide showed potent activity against both bacteria and fun...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3006059/ https://ncbi.nlm.nih.gov/pubmed/21062093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101394r |
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