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Stereo-Selective Metabolism of Methadone by Human Liver Microsomes and cDNA-Expressed Cytochrome P450s: A Reconciliation
In vitro metabolism of methadone was investigated in cytochrome P450 (CYP) Supersomes and phenotyped human liver microsomes (HLMs) to reconcile past findings on CYP involvement in stereo-selective metabolism of methadone. Racemic methadone was used for incubations; (R)-and (S)-methadone turnover and...
में बचाया:
| मुख्य लेखकों: | , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2010
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3005981/ https://ncbi.nlm.nih.gov/pubmed/20825389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-7843.2010.00628.x |
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