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Increased Mitochondrial Thioredoxin 2 Potentiates N-ethylmaleimide-Induced Cytotoxicity
Thioredoxin 2 (Trx2) is a mitochondrially localized antioxidant and anti-apoptotic protein, whose functions are mainly dependent on the conserved cysteines at its redox active center. In the current study, we showed by mass spectrometry that a thiol alkylating agent, N-ethylmaleimide (NEM), alkylate...
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| Main Authors: | , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2008
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3005271/ https://ncbi.nlm.nih.gov/pubmed/18447393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800012p |
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