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Increased Inflammatory Signaling and Lethality of Influenza H1N1 by Nuclear Thioredoxin-1
BACKGROUND: Cell culture studies show that the antioxidant thiol protein, thioredoxin-1 (Trx1), translocates to cell nuclei during stress, facilitates DNA binding of transcription factors NF-κB and glucocorticoid receptor (GR) and potentiates signaling in immune cells. Excessive proinflammatory sign...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3078150/ https://ncbi.nlm.nih.gov/pubmed/21526215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018918 |
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