In Vitro and in Vivo Evaluation of Native Glucagon and Glucagon Analog (MAR-D28) during Aging: Lack of Cytotoxicity and Preservation of Hyperglycemic Effect

BACKGROUND: For automated prevention of hypoglycemia, there is a need for glucagon (or an analog) to be sufficiently stable so that it can be indwelled in a portable pump for at least 3 days. However, under some conditions, solutions of glucagon can form amyloid fibrils. Currently, the usage instruc...

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Main Authors: Ward, W Kenneth, Massoud, Ryan G, Szybala, Cory J, Engle, Julia M, El Youssef, Joseph, Carroll, Julie M, Roberts, Charles T, DiMarchi, Richard D
Formato: Artigo
Idioma:Inglês
Publicado: Diabetes Technology Society 2010
Assuntos:
Symposium
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005040/
https://ncbi.nlm.nih.gov/pubmed/21129325
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