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Optimization of the Native Glucagon Sequence for Medicinal Purposes

BACKGROUND: Glucagon is a life-saving medication used in the treatment of hypoglycemia. It possesses poor solubility in aqueous buffers at or near physiological pH values. At low and high pH, at which the peptide can be formulated to concentrations of a milligram or more per milliliter, the chemical...

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Detalhes bibliográficos
Main Authors: Chabenne, Joseph R, DiMarchi, Maria A, Gelfanov, Vasily M, DiMarchi, Richard D
Formato: Artigo
Idioma:Inglês
Publicado em: Diabetes Technology Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005041/
https://ncbi.nlm.nih.gov/pubmed/21129326
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