Phospholipase D2 Ablation Ameliorates Alzheimer's Disease-Linked Synaptic Dysfunction and Cognitive Deficits

Growing evidence implicates aberrant lipid signaling in Alzheimer's disease (AD). While phospholipases A2 and C have been recently shown to mediate key actions of amyloid β-peptide (Aβ) through a dysregulation of arachidonic acid and phosphatidylinositol-4,5-bisphosphate metabolism, respectivel...

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Detalhes bibliográficos
Main Authors: Oliveira, Tiago Gil, Chan, Robin B., Tian, Huasong, Laredo, Mikael, Shui, Guanghou, Staniszewski, Agnieszka, Zhang, Hong, Wang, Lili, Kim, Tae-Wan, Duff, Karen E., Wenk, Markus R., Arancio, Ottavio, Di Paolo, Gilbert
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004537/
https://ncbi.nlm.nih.gov/pubmed/21147981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3317-10.2010
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