Reduction of Synaptojanin 1 Ameliorates Synaptic and Behavioral Impairments in a Mouse Model of Alzheimer's Disease

Decades of research have correlated increased levels of amyloid-β peptide (Aβ) with neuropathological progression in Alzheimer's disease (AD) patients and transgenic models. Aβ precipitates synaptic and neuronal anomalies by perturbing intracellular signaling, which, in turn, may underlie cogni...

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Main Authors: McIntire, Laura Beth J., Berman, Diego E., Myaeng, Jennifer, Staniszewski, Agnieszka, Arancio, Ottavio, Di Paolo, Gilbert, Kim, Tae-Wan
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2012
主題:
Brief Communications
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711720/
https://ncbi.nlm.nih.gov/pubmed/23115165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2034-12.2012
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