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Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation

Neurodegeneration and synaptic dysfunction observed in Alzheimer's disease (AD) have been associated with progressive decrease in neuronal activity. Here, we investigated the effects of Notoginsenoside R1 (NTR1), a major saponin isolated from Panax notoginseng, on neuronal excitability and asse...

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Библиографические подробности
Главные авторы: Yan, Shijun, Li, Zhi, Li, Hang, Arancio, Ottavio, Zhang, Wensheng
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161968/
https://ncbi.nlm.nih.gov/pubmed/25213453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06352
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